Table 2.
Dihydropyridine-free tissue concentration in hypertensive and normotensive rats after chronic treatment by nisoldipine (80 mg kg−1 a day p.o.) or amlodipine (10 mg kg−1 a day p.o.).
| drug | nisoldipine | amlodipine | ||
|---|---|---|---|---|
| rat strain | decrease in SBP (mmHg) | free tissue concentration | decrease in SBP (mmHg) | free tissue concentration |
| SHR | 79±5.8 | 15–75 pMa | 35±6.9 | 4–6 nMb |
| WKY | n.s. | 15–75 pMa | n.s. | 3–5 nMb |
Data recalculated from Godfraind et al. (1991) and Morel & Godfraind (1994).
a
Estimated from the inhibition of the specific binding of 3H(+) isradipine in heart membrane (nisoldipine).
b
Estimated from the displacement of concentration–contraction curve of Bay K8644 in aortic rings.