TABLE 2.

Doxorubicin efflux rates in yeast mutant strains

Strains	Efflux rate	Relative efflux rate
PDR1	1.5 × 10−4/sec	1
pdr1-3	48 × 10−4/sec	32
pdr1-3 pdr5Δ	1.4 × 10−4/sec	0.93
pdr1-3 nap1Δ	1.2 × 10−4/sec	0.8
pdr1-3 gin4Δ	∼0.4 × 10−4/sec	0.27
pdr1-3 cla4Δ	<0.2 × 10−4/sec	<0.13
pdr1-3 elm1Δ	<0.2 × 10−4/sec	<0.13
pdr1-3 cdc28-C127Y	<0.2 × 10−4/sec	<0.13
pdr1-3 cdc28-Y19F	46 × 10−4/sec	31

The efflux rates of indicated strains were the negative slopes derived from time-course experiments as described in Figure 2D in the absence of FK506. Relative efflux rates were normalized to the PDR1 strain.