TABLE 2.
Standardized difference between observed heterozygosity and its expectation under neutrality equilibrium (HND)
| Population | Region | A | B | C |
|---|---|---|---|---|
| a. HLA data: class I | ||||
| Dogon | SSA | 0.96 | 0.48 | 0.26 |
| Kenyan | SSA | 0.85 | 0.84 | 0.42 |
| Shona | SSA | 0.97 | 1.10 | 1.34 |
| Zulu | SSA | 1.45 | 1.12 | 1.06 |
| Czech | EUR | −0.09 | 1.28 | 1.05 |
| Georgian | EUR | −0.55 | −0.04 | 0.76 |
| Irish | EUR | 0.63 | 0.22 | 1.09 |
| Malay | SEA | 0.48 | 1.18 | 1.15 |
| Puyuma | SEA | −0.87 | 1.41 | 1.20 |
| Saisiat | SEA | 0.08 | −0.96 | −1.70 |
| Yami | SEA | 0.41 | 0.77 | 0.98 |
| Filipino | OCE | 0.49 | 0.87 | 0.06 |
| Ivatan | OCE | 1.16 | 0.80 | 1.12 |
| Yuendumu | AUS | 0.35 | 1.28 | 1.38 |
| Korean | NEA | 1.10 | 1.30 | 1.30 |
| Okinawan | NEA | 0.99 | 1.26 | 1.28 |
| Tuva | NEA | 0.17 | 1.06 | 1.32 |
| Mixe | NAM | 0.55 | −0.18 | 0.61 |
| Yupik | NAM | −1.63 | 0.35 | −0.38 |
| Guarani–Nandewa | SAM | −0.15 | −0.35 | 1.23 |
| Fraction HND > 0 | 15/20 | 16/20 | 18/20 | |
| Overall P-value (FPPa) | 0.045 | 0.000 | 0.000 | |
| Overall P-value (t-test)a | 0.042 | 0.000 | 0.000 | |
| Average HND | 0.367 | 0.690 | 0.777 | |
| Population | Region | DRB1 | DQB1 | DPB1 |
|---|---|---|---|---|
| b. HLA data: class II | ||||
| Shona | SSA | 1.25 | 0.92 | 0.13 |
| Zulu | SSA | 0.13 | 1.41 | |
| Czech | EUR | 0.68 | 1.32 | −0.67 |
| Slovenian | EUR | 1.12 | 1.23 | −0.95 |
| Kinh | SEA | −0.19 | 0.70 | |
| Malay | SEA | −0.61 | 0.64 | 0.13 |
| Muong | SEA | 0.97 | −0.76 | |
| East Timorese | OCE | −1.76 | 1.08 | 0.62 |
| Moluccan | OCE | −0.26 | 0.59 | 0.59 |
| PNG Lowlander | OCE | 0.65 | −0.66 | |
| Cape York | AUS | −0.47 | 0.87 | 0.26 |
| Kimberley | AUS | 0.79 | 0.69 | |
| Canoncito | NAM | −0.02 | −0.07 | 0.49 |
| Mixe | NAM | 0.76 | 1.30 | −1.63 |
| Zuni | NAM | 0.96 | 0.30 | 0.46 |
| Central America | SAM | 0.81 | 1.28 | −1.27 |
| Guarani–Nandewa | SAM | −1.05 | −0.23 | |
| Fraction HND > 0 | 10/17 | 13/17 | 7/11 | |
| Overall P-value (FPP)a | 0.220 | 0.004 | 0.683 | |
| Overall P-value (t-test)a | 0.299 | 0.002 | 0.512 | |
| Average HND | 0.221 | 0.625 | −0.167 | |
| Population | Mean HND | First quartile | Third quartile |
|---|---|---|---|
| c. Frisse data | |||
| Hausa | −0.447 | −0.863 | 0.295 |
| Italian | −0.167 | −0.749 | 0.594 |
| Chinese | −0.303 | −1.267 | 1.072 |
Values for population–locus combinations with a significant uncorrected deviation from neutral-equilibrium expectations are in italics.
a
Overall tests of deviation of a locus from neutrality equilibrium were computed using both Fisher's product of P-values (FPP) method for combining P-values and a t-test for the average HND.