TABLE 1.

Mutations observed in the nth-1 and xpa-1 MA lines

Chr.	Locus	Locus pos.	Mut.	Context	Line(s)	Cod.
nth-1
I	ZK337	25,889	A → G	TCACG → TCGCG	N-20	EX (R: H → R)
I	ZK337	26,580	T → C	TCTCT → TCCCT	N-24	EX (R: L → P)
I	ZK337	25,984	C → G	AACGT → AAGGT	N-34	EX (R: R → G)
I	ZK337	25,648	T → G	AGTGC → AGGGC	N-35	EX (S)
II	C17G10	23,624	T → C	GGTCT → GGCCT	N-46	IG
II	C17G10	23,629	T → C	TTTCC → TTCCC	N-46	IG
II	M106	19,396	A → G	TAAAG → TAGAG	N-06	IG
II	M106	19,453	A → C	CCAAA → CCCAA	N-08	IG
V	W05B10	20,887	+G	CTCT → CTGCT	N-04	IG
X	F19C6	3,776	T → C	CATTT → CACTT	N-49	IN
X	F19C6	3,997	T → G	TCTAA → TCGAA	N-08	IN
X	C07A4	11,775	G → A	ACGTT → ACATT	N-25	IN
X	C07A4	11,638	A → G	GGAGA → GGGGA	N-35	EX (S)
X	F59F5	22,175	A → C	AAATT → AACTT	N-24	IN
X	F59F5	21,782	+T	TACT → TATCT	N-41	IN
xpa-1
II	C17G10	24,313	C → T	TTCAA → TTTAA	A-04	IG
II	M106	19,445	C → G	GGCGG → GGGGG	A-48	IG
II	M106	19,440	A → C	GGAGA → GGCGA	A-08	IG
II	M106	19,481	C → G	GCCAA → GCGAA	A-24	IG
II	M106	19,554	T → G	GGTGC → GGGGC	A-37	IG
II	M106	19,557	A → G	GCACA → GCGCA	A-37	IG
II	Y48G9A	119,086	C → G	CCCAG → CCGAG	A-41	IG
V	B0240	2,189	(T)6 → (T)7	TC(T)6CA → TC(T)7CA	A-46	IN
V	B0240	2,447	A → G	GGAGT → GGGGT	A-05	IN
V	W05B10	21,606	T → A	AGTGA → AGAGA	A-17	IG
V	WO5B10	21,579	G → A	ATGAA → ATAAA	A-35, A-46	IG
V	Y113G7A	4,758	+C	CAAC → CACAC	A-41	IG
X	R03E9	21,601	−A	ATAGA → ATGA	A-16	EX (FS)
X	R03E9	22,136	(G)4 → (G)5	GA(G)4CA → GA (G)5CA	A-43	EX (FS)
X	R03E9	21,839	+T	AGAT → AGTAT	A-50	IN
X	F19C6	3,530	T → C	TTTCC → TTCCC	A-32	IN
X	F59F5	22,287	T → A	ATTTG → ATATG	A-03	EX (R: N → Y)
X	F59F5	22,421	T → G	CATCG → CAGCG	A-03	EX (R: H → P)
X	F59F5	21,815	G → A	AAGTT → AAATT	A-28	IN
X	F59F5	21,825	T → G	AATAC → AAGAC	A-28	IN
X	F59F5	21,785	G → A	TTGTT → TTATT	A-31	IN
X	F59F5	21,860	(C)3 → (C)2	AG(C)3AC → AG(C)2AC	A-13, A-21	IN

Chr. indicates the chromosome in which the mutation was found. Locus refers to the sequenced C. elegans cosmid or yeast artificial chromosome in which the mutation was found (PCR loci surveyed for mutation are named according to C. elegans cosmids, fosmids, and yeast artificial chromosomes; see supplemental Table 1 for details). Mut. refers to the observed mutation. Context provides information regarding the bases surrounding the observed mutation with respect to the (+) strand of C. elegans chromosomes. Line indicates the specific MA line in which the mutation was detected. Cod. refers to the coding context of the sequence in which the mutation was found: EX, exon, IG, intergenic, and IN, intron. For exon base substitution mutations, S indicates a silent base substitution and R indicates a replacement base substitution (amino acid change is indicated after R). EX (FS) denotes a mutation predicted to result in a frameshift in an open reading frame.