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. 2006 Aug 24;6:214. doi: 10.1186/1471-2407-6-214

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Copyright © 2006 Mühlethaler-Mottet et al; licensee BioMed Central Ltd.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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SiRNAs-mediated down-regulation of survivin expression. A Whole cell extracts of SH-EP cells transfected for 40 h with lipofectamine2000 alone (lipo), with survivin siRNA (25 or 100 nM), control siRNA (100nM), or untransfected (no) were analysed by immunoblotting for the presence of survivin and β-actin as loading control.B Survivin down-regulation by siRNAs sensitise NB cells to HDACIs. SH-EP cells were untransfected (no), transfected with lipofectamine 2000 (lipo) alone or with survivin siRNA (100 nM) or control siRNA (100 nM), and treated 40 h after transfection with the indicated amounts of NaB (mM), SAHA, TSA (μM) and TRAIL (ng/ml). Cell death was measured by MTS/PMS cell proliferation assays.