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. Author manuscript; available in PMC: 2006 Sep 18.
Published in final edited form as: Nature. 2005 Dec 4;439(7074):344–348. doi: 10.1038/nature04388

Figure 1.

Figure 1

A restricted quasispecies of poliovirus is less neuropathogenic. a–b, Percentage of mice surviving intramuscular injection of different doses (107, 108, 109 PFU) of the narrow G64S (a) or the expanded G64SeQS populations (b) as compared to wildtype (WT, open symbols, only one dose, 107 PFU is shown). The number of mice per group was 20 (n=20). The differences observed between WT (107 PFU) and G64S (107, 108, 109 PFU) or the expanded G64SeQS (107 PFU) are statistically significant (P<0.001). In contrast, no statistically significant difference was observed between WT (107 PFU) and G64SeQS (108 PFU) (p>0.5). c, Calculation of LD50 values for each viral stock using the Reed and Muench method.