Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2006 May 9;114(9):1450–1456. doi: 10.1289/ehp.8691

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Publication of EHP lies in the public domain and is therefore without copyright. All text from EHP may be reprinted freely. Use of materials published in EHP should be acknowledged (for example, ?Reproduced with permission from Environmental Health Perspectives?); pertinent reference information should be provided for the article from which the material was reproduced. Articles from EHP, especially the News section, may contain photographs or illustrations copyrighted by other commercial organizations or individuals that may not be used without obtaining prior approval from the holder of the copyright.

PMC Copyright notice

Postulated metabolism scheme for trichloroethylene. Figure adapted from Clewell et al. (2000) and Lash et al. (2000a). For the GSH pathway, metabolism to 1,2-DCVG is shown, but 1,1-DCVG goes through similar steps through 1,1-DCVC to N-acetylated and reactive species.

Abbreviations: ADH, alcohol dehydrogenase; BL, cysteine conjugate β-lyase; CDH, chloral dehydrogenase (aldehyde oxidase); CGDP, cysteinyl-glycine dipeptidase; CH, chloral hydrate; CHL, chloral; DCA, dichloroacetic acid; DCVC, S-dichlorovinyl-l-cysteine; DCVCS, 1,2-DCVC sulfoxide; DCVG, S-dichlorovinyl glutathione; EHR, enterohepatic recirculation; FA, formic acid; FMO, flavin-containing monooxygenase; GA, glyoxylic acid; GGTP, γ-glutamyl transpeptidase; GST, glutathione S-transferase; MCA, monochloroacetic acid; MFO, mixed-function oxidase (i.e., cytochrome P450); NAT, N-acetyltransferase; NADCVC, N-acetyl-1,2-DCVC; OA, oxalic acid; TCE-O-P450, oxygenated TCE-cytochrome P450 transition state complex; TCA, trichloroacetic acid; TCOG, trichloroethanol glucuronide; TCOH, trichloroethanol; UGT, uridine diphosphate-glucuronosyltransferase.