Skip to main content
. 2006 May 15;103(21):8221–8226. doi: 10.1073/pnas.0602620103

Fig. 3.

Fig. 3.

Effect of SDF-1 on vasotocin-induced AVP release. Perifusion of hypothalamic tissues with 100 nM vasotocin for 30 min induces a 10-fold increase in AVP release. The effect is already observed after 10-min infusion with the peptide. SDF-1 (50 nM) significantly blunts vasotocin-induced AVP release. The inhibitory effect of SDF-1 is totally blocked by the CXCR4 antagonist AMD (10 μM). Results are expressed as Δ (% increase in AVP release per hypothalamus), mean ± SEM of three experiments. ∗, P < 0.05; and ∗∗, P < 0.01 vs. basal level.