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. 2006 Sep 15;2(9):e123. doi: 10.1371/journal.pcbi.0020123

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© 2006 Chickarmane et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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The system is a bistable switch with respect to the B ₋ concentration. As the threshold is crossed (B ≈ 36, arbitrary units), NANOG turns off, and OCT4 and SOX2 are reduced to lower levels. Since the signal is still present (A ₊ = 100), the OCT4 and SOX2 levels do not decline to very low levels.