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. 2006 Sep 15;2(9):e123. doi: 10.1371/journal.pcbi.0020123

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© 2006 Chickarmane et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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(A) Shows the OCT4–SOX2 and NANOG concentration showing irreversible bistability, when NANOG is overexpressed through a high value for the basal rate of transcription (i.e., η ₅). Hence its expression remains on even on removal of the signal A ₊.

(B) Shows OCT4–SOX2 and NANOG concentrations (the same as in Figure 3) exhibiting bistable behavior, which have negligible basal rates of transcription for NANOG, but which require the signal for the stem cell box to be on.