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. 2006 Sep 21;116(10):2643–2652. doi: 10.1172/JCI27306

Figure 4. Human cytotrophoblasts stimulate lymphatic endothelial cell migration in vitro.

Figure 4

(A) The addition of cytotrophoblast-conditioned medium to the lower compartment of a Transwell chamber significantly increased human dermal lymphatic endothelial cell migration compared with controls. The effect, similar to that of a growth factor medium (GFM) control, was abolished by heat inactivation (HI). (B) The addition of VEGFR1-Fc, VEGFR3-Fc, anti–FGF-2, and anti–TNF-α, but not anti-PDGF or Tie-2–Fc, inhibited cytotrophoblast-stimulated lymphatic endothelial cell migration compared with nonimmune mouse IgG or CD6-Fc. Values are mean ± SEM of multiple experiments. *P < 0.016 versus control.