Table 1.
Baseline characteristics of the study groups (mean ± SD).
Group 1 | Group 2 | Group 3 | ||||
| ||||||
---|---|---|---|---|---|---|
Control | Long standing IDDM | Newly diagnosed IDDM | ||||
(C) | (LS-IDDM) | (ND-IDDM) | ||||
| ||||||
Before treatment | After treatment | P-value | ||||
(BT) | (AT) | |||||
| ||||||
n | 25 | 15 | 12 | 12 | ||
| ||||||
Glucose (mg/dL) | 84.8 ± 13.8 | 158.3 ± 21.7 | 470.9 ± 98.1a, b | 145.5 ± 24.4 | aP < .01 | ND-IDDM versus C |
ND-IDDM versus | ||||||
LS-IDDM | ||||||
bP < .01 | LS-IDDM versus C | |||||
P < .001 | ND-IDDM | |||||
(BT versus AT) | ||||||
| ||||||
HbA1c (%) | 5.3 ± 0.7 | 8.0 ± 1.2b | 9.9 ± 1.4a | 8.6 ± 1.1 | aP < .01 | ND-IDDM versus C |
ND-IDDM versus | ||||||
LS-IDDM | ||||||
bP < .01 | LS-IDDM versus C | |||||
P < .05 | ND-IDDM | |||||
(BT versus AT) | ||||||
| ||||||
Microalbuminuria (mg/L) | 6.4 ± 1.0 | 8.1 ± 1.5 | 10.2 ± 3.8a | 9.4 ± 2.9 | aP < .001 | ND-IDDM versus C |
ND-IDDM versus | ||||||
LS-IDDM | ||||||
| ||||||
Urea (mg/dL) | 21.8 ± 4.2a | 30.7 ± 6.6b | 38.1 ± 10.6 | 31.4 ± 11.8 | aP < .01 | C versus LS-IDDM |
C versus ND-IDDM | ||||||
bP < .05 | ND-IDDM versus | |||||
LS-IDDM | ||||||
P < .05 | ND-IDDM | |||||
(BT versus AT) | ||||||
| ||||||
Creatinine (mg/dL) | 0.5 ± 0.1 | 0.8 ± 0.1 | 0.9 ± 0.2a | 0.8 ± 0.2 | aP < .01 | ND-IDDM versus C |
ND-IDDM versus | ||||||
LS-IDDM | ||||||
| ||||||
Creatinine clearance (ml/dk) | 80.5 ± 10.6a | 56.7 ± 10.9 | 52.4 ± 13.7 | 50.1 ± 14.1 | aP < .01 | C versus LS-IDDM |
C versus ND-IDDM | ||||||
| ||||||
ASO (U/mL) | 0.2 ± 0.04a | 1.5 ± 0.3 | 2.0 ± 0.5 | 1.3 ± 0.4* | aP < .01 | C versus LS-IDDM |
C versus ND-IDDM | ||||||
P < .05 | ND-IDDM | |||||
(BT versus AT) | ||||||
| ||||||
CRP (mg/L) | 0.3 ± 0.04 | 0.9 ± 0.2 | 1.3 ± 0.4a | 0.9 ± 0.3 | aP < .05 | ND-IDDM versus C |
ND- IDDM versus | ||||||
LS-IDDM | ||||||
| ||||||
WBC (/mm3) | 7745 ± 1412 | 12126 ± 3611a | 9294 ± 1647 | 8548 ± 1593 | aP < .05 | LS-IDDM versus C |
LS-IDDM versus | ||||||
ND-IDDM |