Figure 3.

Genomic structure and alternative splicing of the 5' regions of murine and human FAK genes. Genomic structure of the 5'-untranslated region of mouse (A) and human (B) FAK genes with reported transcripts and ESTs from each species. The lengths (bp) of DNA fragments are shown on top of each genomic gene structure. The characterized human promoter [47] is symbolized with black dots (Prom) in B, and the conserved regions located on the mouse gene are indicated (Prom) in A. Exons -1, -2, -3, and -4 are conserved between mouse and human (87% 60%, 72% and 74% identity respectively) and indicated by open boxes. Species specific exons are indicated by grey boxes. Human exons -4, -3bH, and -2 as well as all murine exons were already annotated in NCBI gene Entrez and Ensembl databases. The accession number of each transcript is reported. Dashed lines indicate putative splicing of mouse transcripts with incomplete 5' UTR regions (ESTs [DDBJ:BY086996, GenBank: CN525831]