Table 2.

Selected recent gene transfer clinical trials.

Cancer	Transferred genes	ClinicalTrials.gov47 identifier #	Description	Phase
Pancreatic	Rexin-G	NCT00121745	A cytocidal cyclin G1 construct accumulates preferentially in the tumor cells to block the action of cyclin G1 and initiate cell death	I
Glioblastoma	HSVtk	NCT00001328	The HSVtk gene is introduced into glioblastoma cells via a mouse retrovirus. Glioblastoma cells with the HSVtk gene are then sensitive to the drug glanciclovir which is administered	I
Head and neck	p53	NCT00041613	Transfer of the p53 gene via a replication incompetent adenovirus to tumor cells to inhibit cell growth and induce apoptosis	III
Melanoma	MDA-7	NCT00116363	MDA-7 a novel tumor suppressor molecule is introduced into the melanoma cells and overexpression inhibits cellular proliferation and induces apoptosis	II
Pancreatic	TNF-α	NCT00051467	The TNF-α gene under the control of a radiation inducible promoter is introduced into tumor cells and in combination with the radiation therapy induces cell death	II

HSVtk, herpes simplex virus thymidine kinase; TNF-α, tumor necrosis factor alpha