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Definition of mutated HIV-2RODProtease susceptibility to LPV and SQV
| IC50 [μM] | IC50mutant/IC50ROD | |||
| HIV-2 Protease mutant | LPV | SQV | LPV | SQV |
| L90M | 12.5+/-8.1 | 554.1+/-3.9 | 0.75 | 3.70 |
| L99F | 11.1+/-3.1 | 147.2+/-5.1 | 0.67 | 0.98 |
L90M and L99F HIV-2ROD mutated Proteases were expressed in yeast. IC50 values to LPV and SQV were defined as in Fig 2A.
