Fig. 1.

Semi-thin sections of ventral spinal roots from P0+/− /RAG-1−/− mice that received no bone marrow (A), or bone marrow from wild-type mice (B), or bone marrow from RAG-1−/− mice (C). For comparison, ventral spinal roots from genuine P0+/− mice are shown (D). Note that demyelination is mild when no bone marrow (A) or bone marrow from RAG-1−/− mice had been transplanted (C), whereas in P0+/− /RAG-1−/− mutants that had received bone marrow from wt mice (B) demyelination is similarly severe as in genuine P0+/− mice (D). Bv, blood vessel. Scale bar in D (for A-D): 20 μm.