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(A,B) Electron microscopy of ventral roots of 6-month-old P0+/− op/wt (heterozygous osteopetrotic (op) mice with wildtype-like M-CSF expression; A) and of P0+/− op/op littermates (homozygous op mice which are M-CSF-deficient; B). In many fibres of P0+/− op/wt mice, there is profound demyelination when compared to P0+/− op/op littermates deficient in M-CSF. Scale bars: 5 μm.
