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Mechanisms reducing endothelial permeability
| • Receptor blockade (H1 antagonists) |
| • Cyclic AMP elevation |
| • Cyclic GMP/NO (lung, large vessels) |
| • PKC inhibition (bovine, porcine EC) |
| • Rho and Rho kinase inhibition |
| • Inhibition of leucocyte adhesion and activation (anti-LFA-1, anti-ICAM-1) |
| • Inhibition of VEGF induced leakage (anti-VEGF antibodies, VEGF receptor tyrosine kinase inhibitor SU5416, Angiopoietin) (tumour vascular bed) |
