Figure 1.
Effect of CB1 agonists of the tone of phenylephrine-precontracted mesenteric artery rings. Concentration-response curves showing the relaxant effect of (A) HU 210, (B) Δ9-THC and (C) anandamide on rings of rabbit mesenteric artery precontracted to 80% of the maximal KCl-induced response with phenylephrine. Experiments were performed using endothelium-intact (+E) and -denuded (−E) arteries in the absence and presence of diclofenac (diclo, 10 μM). Results are presented as the mean±s.e.mean of 12 separate experiments.