Figure 2.

Effect of CB1 agonists on the EDHF-mediated relaxation of the rabbit mesenteric artery. Concentration-response curves to acetylcholine (ACh) were obtained using phenylephrine precontracted mesenteric artery rings in the presence of either solvent (0.06% ethanol), SR 141716A (30 μM), HU 210 (30 μM; A), Δ⁹-tetrahydrocannabinol (Δ⁹-THC, 30 μM; B), anandamide (30 μM; C) or combinations of CB1 agonist and SR 141716A. All experiments were performed in the continuous presence of N^Gnitro-L-arginine (100 μM) and diclofenac (10 μM) and the results are presented as the mean±s.e.mean of nine separate experiments.