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. 1999 Feb;126(4):1041–1049. doi: 10.1038/sj.bjp.0702390

Figure 3.

Figure 3

Dose-response curves of sulprostone-induced inhibition of AVP-dependent cyclic AMP accumulation in the rat MTAL and OMCD. Different concentrations of sulprostone were tested on cyclic AMP accumulation induced by 1 nM (OMCD) or 10 nM (MTAL) AVP in the presence of 50 μM Ro 20-1724. The results are expressed in percentage of the corresponding response obtained with AVP. The data are the mean values±s.e.mean calculated from three experiments in the MTAL and from four experiments in the OMCD. In each experiment, a statistical significant inhibition was observed from a concentration of either 0.1 nM in the MTAL (P<0.005–0.001 versus the corresponding AVP value) or 0.1 μM in the OMCD (P<0.025–0.005).