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The potentiation of the inhibitory effect of a PDE4 inhibitor (RP73401) by exogenous PGE2 on LPS-induced TNF-α production (4 h incubation). (a) Effect of exogenous PGE2 alone. (b) Effect of RP73401 in the absence or presence of PGE2. n=3 donors. *P<0.05 and **P<0.01 vs RP73401 alone.
