Figure 4.
Rectal temperature of rats receiving L-DOPA (25 mg kg−1 i.p.+benserazide 6.25 mg kg−1 i.p.) 2 h after MDMA (15 mg kg−1 i.p.) or saline. Also shown are the rectal temperature of animals injected with saline instead of L-DOPA and administered 2 h before saline or MDMA. There was no difference in the basal temperature of the groups. MDMA produced a significant rise in body temperature (F(1,9)=129.36, P<0.001) compared with the saline injected group. Administration of L-DOPA to MDMA-treated rats produced a prolongation of the hyperthermic response induced by MDMA (F(1,11)=4.12, P<0.05).