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β-gal activity is retained in the islets but declines in the acini. (A) X-gal staining is absent in some acini in a PN7 transgenic male. (B) Complete loss of acinar β-gal activity in a PN12 weeks homozygous female. Specimens stained with X-gal and immunoperoxidase-stained for glucagon. Scale bar = 100 µm.
