Fig. 6.

The effect of stimulus lateralization and attention on statistical maps for each experimental condition. RA = attend to pain on right hand, RV = attend to visual stimulus during pain to right hand. L replaces R for experiments with pain delivered to the left hand. The distribution of activation sites is shown on coronal sections taken through the insula and Talairach y-coordinates shown below each image [activated voxels are significant at P (corrected) < 0.05]. Images are displayed using neurological convention, i.e. right is right, left is left. Attended painful stimulation activated more rostral regions of the anterior insula than distracted stimulation (see yellow circles on anterior coronal sections). Also demonstrated is the effect of stimulus laterality on activation of posterior insula cortex (foci of activity are highlighted with coloured circles: right-hand stimulation, red; left-hand stimulation, blue). Posterior insula activity switched sides when the stimulus was transferred from hand to hand and did not depend on the attentional context during stimulation. Reproduced with permission (Brooks et al. 2002).