Figure 6.

Voltage-dependence of the basilen blue induced inhibition of IC1,swell. (A) Current traces in response to voltage steps ranging from +20 to +140 mV (increment is 20 mV) from a holding potential of −50 mV after full activation of I_C1,swell by applying a 25% hypotonic stimulus in control solutions and in the presence of 1, 3 or 10 μM basilen blue (upper panels from left to right). Note the time-dependent decay of the current in the presence of the inhibitor. (B) Voltage-dependence of inhibition, expressed as a percentage of total current, and time constant of inhibition calculated from the traces in A. The solid lines represent the fits of the data points to equation [2].