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. 1999 Sep;128(2):435–443. doi: 10.1038/sj.bjp.0702777

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Copyright 1999, Nature Publishing Group

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Concentration–response profiles of nitrovasodilator-induced relaxations. Relaxations were calculated as the per cent reversal of the KCI-induced pre-constriction as determined in each individual experiment. Relaxations were induced by: (A) Spermine/nitric oxide complex (SPNO); (B) nitric oxide (NO, released from SPNO); (C) 3-morpholinosydnonimine (SIN-1); (D) nitroprusside; (E) S-nitroso-N-acetylpenicillamine (SNAP); or (F) nitroglycerin (NTG). Symbols denote the mean (±s.e.mean) relaxation at each concentration of nitrovasodilator. The equation of each curve is defined by the mean values of the maximal dilation, the Hill coefficient and the pEC₅₀.

Concentration–response profiles of nitrovasodilator-induced relaxations. Relaxations were calculated as the per cent reversal of the KCI-induced pre-constriction as determined in each individual experiment. Relaxations were induced by: (A) Spermine/nitric oxide complex (SPNO); (B) nitric oxide (NO, released from SPNO); (C) 3-morpholinosydnonimine (SIN-1); (D) nitroprusside; (E) S-nitroso-N-acetylpenicillamine (SNAP); or (F) nitroglycerin (NTG). Symbols denote the mean (±s.e.mean) relaxation at each concentration of nitrovasodilator. The equation of each curve is defined by the mean values of the maximal dilation, the Hill coefficient and the pEC₅₀.