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. 1999 Sep;128(2):458–464. doi: 10.1038/sj.bjp.0702786

Figure 4.

Figure 4

Effect of EFS (submaximal voltage, 0.2 ms) train length on the sensitivity of NANC inhibitory responses to L-NOARG (10 μM) and α-chymotrypsin (2 U/ml). (a) Overlaid representative tracings of responses from a single preparation, showing that although the amplitude of responses to increasing numbers of pulses (40, 120 and 240) was similar between 4 and 16 Hz, responses to 16 Hz EFS were more prolonged. (b,c) Grouped data showing the inhibitory effect of L-NOARG and L-NOARG+α-chymotrypsin on EFS-induced responses. All experiments were conducted on PGF2α-contracted preparations in the presence of indomethacin (3 μM), bretylium (1 μM) and atropine (1 μM). All points represent results from eight experiments. *Indicates significant inhibition of responses by L-NOARG (P<0.05, paired t-test); †indicates significant effect of α-chymotrypsin (P<0.05, paired t-test).