Figure 4.

Fraction of theophylline metabolic clearance generating 3-methylxanthine (3MX), 1-methyluric acid (1MU) and 1,3-dimethyluric acid (1,3DMU) following the intravenous administration of 2.5 mg kg⁻¹ of theophylline to controls conscious rabbits, rabbits with a turpentine-induced inflammatory reaction, and rabbits with an inflammatory reaction and acute moderate hypoxia (PaO₂≈55 mmHg) for 24 h. Vertical bars are s.e.mean. ^*, ^**P<0.05 compared with the control or with inflammation alone, respectively.