Figure 5.

Fraction of theophylline metabolic clearance generating 3-methylxanthine (3MX), 1-methyluric acid (1MU) and 1,3-dimethyluric acid (1,3DMU) following the intravenous administration of 2.5 mg kg⁻¹ of theophylline to control conscious rabbits, to control rabbits receiving corn oil s.c., to rabbits receiving 3-methylcholanthrene (3MC) (80 mg kg⁻¹ s.c.) or to rabbits receiving 3MC and subjected to acute moderate hypoxia (PaO₂≈35  mmHg) for 24 h. Vertical bars are s.e.mean. ^*P<0.05 compared with the control or with 3MC alone, respectively.