Figure 2.

Effect of DPCPX (3.3×10⁻⁶ mol kg⁻¹ i.v.), or its vehicle (1 ml kg⁻¹ i.v.), on mean arterial pressure (MAP) and heart rate (HR), and on peak changes in MAP and HR produced following administration of saline (1 ml i.v.), GR79236 (3×10⁻⁸ mol kg⁻¹ i.v.), or application of ischaemic preconditioning (5 min ischaemia followed by 5 min reperfusion). In each pair of histobars, the first bar shows the effect of treatment 1, and the second bar shows the effect of treatment 2. Data are expressed as mean percentage peak change in MAP and HR±s.e.mean (n=6–7). ^*Pre-treatment with DPCPX produced a significant (P<0.01) increase in MAP and HR compared to pre-treatment with vehicle. #GR79236-induced peak reductions in MAP and HR after pre-treatment with DPCPX are significantly (P<0.01) smaller than after pre-treatment with vehicle.