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. 1999 Sep;128(2):486–492. doi: 10.1038/sj.bjp.0702802

Figure 3.

Figure 3

Zn2+ ions modulate ATP activity at P2X (Group 1) receptors. (A) Whole-cell inward currents evoked by ATP (0.3 μM, approx. EC50) before, during and after washout of Zn2+ (10 μM; 20 min pre-incubation; at pH 7.5) at rP2X1 receptors. All records from the same oocyte (Vh=−60 mV). (B) Whole-cell inward currents to ATP (0.3 μM, approx. EC20) before, during and after washout of Zn2+ (100 μM; 0 min pre-incubation; at pH 7.5). All records from the same oocyte (Vh=−60 mV). Note that the Zn2+ effect at rP2X1 and rP2X3 receptors reversed on washout (20 min).