Figure 4.

Effects of a continuous i.c.v. infusion of Aβ on performance in the working memory test of the water maze task in sham-operated and ovariectomized female rats. The continuous i.c.v. infusion of Aβ was started 3 months after the ovariectomy. The working memory test (five trials per day) was carried out on days 14–16 after the start of the Aβ infusion. Changes in the mean escape latency and swimming distance for 3 days during five trials are shown in (A) and (B), respectively. The mean escape latency and swimming distance in the test trials (second trial) for 3 days are shown in (C) and (D), respectively. Values indicate means±s.e.mean (n=8–9). ^*P<0.05 vs sham-Aβ-(40-1).