Figure 3.

Changes of forskolin-stimulated cyclic AMP production induced by CP55940, O-1184 and O-1238, (a) in CB₁- and (b) in CB₂-transfected CHO cells and by O-584 and O-1315, (c) in CB₁- and (d) in CB₂-transfected CHO cells. Each symbol represents mean percentage change in forskolin-stimulated cyclic AMP production±s.e.mean. Forskolin-stimulated cyclic AMP production in the absence of any cannabinoid has been normalized to 100%. See Table 1 for further details. None of the concentrations of O-1238 or O-1315 used caused cyclic AMP production by CB₂-transfected CHO cells to deviate significantly from 100% (P>0.05; one-sample t-test).