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. 1999 Oct;128(3):802–808. doi: 10.1038/sj.bjp.0702843

Figure 1.

Figure 1

Modification of relaxations induced by acetylcholine (ACh) and sodium nitroprusside (SNP) by endothelium denudation (E−), L-NOARG, L-arginine, (L-Arg), and carboxy PTIO in monkey lingual arteries. The ordinate denotes relaxations relative to those induced by papaverine (0.1 mM). Numbers in parentheses indicate the number of strips from individual monkeys. Upper left and right, effect of endothelium denudation on responses to acetylcholine and nitroprusside, respectively. Lower left, inhibition by L-NOARG (10 μM) of acetylcholine action and reversal by L-arginine (1 mM); lower right, effect of carboxy PTIO (0.3 mM) on acetylcholine action in L-NOARG (100 μM)-treated strips. Significantly different from control (E+), ‡P<0.001 (unpaired t-test). Significantly different from control, *P<0.01; significantly different from the value with L-NOARG+L-arginine, †P<0.01; ≈rcub;P<0.05 (Tukey's test). Vertical bars represent s.e.mean.