Figure 4.

Modifications by metyrapone (1 mM), proadifen (10 and 30 μM), lauric acid (10 μM), and debrisoquine (10 μM) of relaxations induced by acetylcholine in monkey lingual arteries with intact endothelium in the presence of indomethacin (1 μM) and L-NOARG (0.1 mM). The ordinate denotes relaxations relative to those induced by papaverine (0.1 mM). Numbers in parentheses indicate the number of strips from individual monkeys. Significantly different from control, †P<0.05 (unpaired t-test for upper left). Significantly different from control, ^*P<0.01; †P<0.05 (Tukey's test for upper right); significantly different between the values with proadifen 10 and 30 μM, ≈rcub;P<0.001 (unpaired t-test). Vertical bars represent s.e.mean.