Figure 7.

Responses to CYP products of endothelium-denuded monkey lingual artery strips in the presence of indomethacin (1 μM) and L-NOARG (0.1 mM) as affected by exposure to high K⁺ media (K⁺ 15 mM) and treatment of the strips with charbdotoxin (ChTX; 30 nM plus apamin (1 μM), iberiotoxin (IBTX; 100 nM), and by treatment of the reaction mixture with ketoconazole (10 μM). The ordinate denotes relaxations relative to those induced by papaverine (0.1 mM). The ‘control' denotes the response to the reaction mixture with full components (liver microsome as enzyme preparation, aracidonic acid and NADPH). n, the number of strips from individual monkeys. Significantly different from control, ^*P<0.001; †P<0.01 (unpaired t-test). Vertical bars represent s.e.mean.