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(A) Original registration showing the contraction and rhythmic activity induced by phenylephrine (PE, 10 μM) and relaxation induced by acetylcholine (Ach, 10 μM) in thoracic aortic rings of E°×LDLR° mice. (B) pretreatment of the vessels with 1 mM TEA for 10 min before addition of PE abolished PE-induced rhythmic activity and reduced the relaxation to Ach without affecting basal tension.
