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Aprikalim-induced relaxation of arterioles adjacent to the sciatic nerve in control and diabetic rats. The KATP-channel opening agent, aprikalim, was added to the external bathing media of pressurized arterioles constricted with U46619. Aprikalim produced similar concentration dependent relaxations in arterioles from control (n=6) and diabetic rats (n=5). Maximal dilation was 92±4 vs 80±8%, −log ED50 was 6.7±0.3 vs 6.7±0.2, respectively.
