Figure 2.

Effect of Nω-nitro-L-arginine (L-NOARG), Nω-nitro-L-arginine methyl ester (L-NAME), tetrodotoxin (TTX) and 3 μM nadolol in combination with 3 μM phentolamine on 30 μM nicotine-induced NANC relaxations of longitudinal muscle strips of rat gastric fundus. Experiments were performed in the presence of 1 μM atropine and 3 μM guanethidine (except for the phentolamine/nadolol experiments) during a 0.1 μM 5-HT-induced contraction. Open bars represent the control relaxations for each set of experiments. Results are shown as the means±s.e.mean and expressed as percentage of decrease of the 5-HT-induced contraction for n=3–5. ^*P value <0.05, significant different from time corrected controls.