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Comparison of agonist-evoked cyclic AMP responses at the wild-type PAC1 receptor and the P1V chimaeric receptor construct. COS 7 cells transiently expressing the wild-type PAC1 receptor or the P1V chimaeric construct were preincubated with IBMX for 15 min before stimulation for 5 min with agonists: (a) PACAP-38; (b) VIP; (c) helodermin. All values are means ±s.e.mean (n=4–12). Error bars not shown fall within the dimensions of the symbol.
