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. 1999 Nov;128(6):1165–1174. doi: 10.1038/sj.bjp.0702901

Figure 8.

Figure 8

Effect of Me5 on mean open times of sodium channels recorded in the presence of ATX in a cell-attached patch of rat skeletal muscle fibre. (A) Typical open-time histogram constructed using the half-amplitude criterion from current traces elicited at −20 mV in a cell-attached patch in the absence of toxin. (B,C) Open-time histograms were constructed from current traces elicited at −20 mV in a cell-attached patch in the presence of ATX as in Figure 6A, before (B) and after (C) application of 10 μM Me5. Overlapping events and closed-time shorter than 0.4 ms were not included in the histograms. The sampling frequency of currents was 10 kHz and the histogram bin width was 100 μs. Excluding initial low-counts bins, data in (A) were well fitted with a mono-exponential function whereas data in (B) and (C) were best fitted with a two-exponential function. The exponential time constants (τ in A, τfast and τslow in B and C) give values of mean open times.