Figure 2.
Effects of glibenclamide on the quasi steady state current of human atrial myocytes elicited by a voltage ramp from −100 to +60 mV (0.08 V s−1). (a) Ramp response under control conditions, under the influence of glibenclamide (50 μM) and after washout. (b) Glibenclamide sensitive current obtained by digital subtraction (data a). The glibenclamide sensitive current is similar to the 4-AP (500 μM) sensitive current shown in (c) and differs completely from IK(ATP) which is shown in (e) as the current activated by cromakalim (100 μM). (d) Glibenclamide sensitive current in the presence of 4-AP (1 mM). Drug sensitive currents were obtained by digital subtraction.