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Glibenclamide induced block of Ito1 in human ventricular myocytes. (a) Outward current recordings (+40 mV) in control and after superfusion with glibenclamide (30, 100 μM). The late current (Ilate) was not affected by glibenclamide. (b) Current voltage relationship of Ito1 and Ilate under control conditions and under influence of glibenclamide (100 μM; closed symbols, n=4). (c) Concentration dependence of Ito1 inhibition by glibenclamide. (**P<0.01; *P<0.05).
