Figure 2.

Dose-dependant effects of SR 57746A on survival of purified mouse motoneurons. Purified mouse motoneurons were incubated at 37°C with a range of SR 57746A concentrations from 0.25–5 μM immediately after seeding. For control cultures, DMSO (0.02%) was added to the medium instead of the drug. Motoneuron counting was performed at 48, 96 and 120 h as described in Methods. Results are expressed as a mean percentage of surviving motoneurons±s.e.mean for two independent experiments. ^*P<0.05, ^**P<0.01, ^***P<0.001 (ANOVA test, followed by Fisher test for multiple comparisons).