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Linear regression analysis. (a) Log IC50 values for inhibition of antigen-stimulated T-cell proliferation vs values for inhibition of hrPDE4A (left, r=0.863, P=0.003) or hrPDE4D (right, r=0.552, P=0.123). (b) Log IC50 values for inhibition of LPS-stimulated TNFα release from human monocytes vs log IC50 values for inhibition of hrPDE4A (left, r=0.899, P=0.0004) or hrPDE4D (right, r=0.483, P=0.157).
