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Inhibition of C5a-induced spasmogenesis by linear and cyclic C5a antagonists. Concentration response curves for C5aWT in human umbilical artery were performed after a 10 min incubation with MeFKPdChaWr (A) or F-[OPdChaWR] (B). Force of contraction relative to a supramaximal concentration of histamine was then measured. Data for each point is expressed as a percentage of the maximum C5a response of each day. The mean value is shown±s.e. (n=3–6).
