Figure 3.

Inhibition of K_V in CGNs by 10 μM fluoxetine does not require the channels to be open. Currents were activated by adapting protocol 1 (see Results). Current recordings in (A) were taken under control and drug conditions. The latter represents maximal inhibition. Only three traces have been shown for clarity, which have not been leak subtracted. The time-course relationship (B) illustrates the protocol more clearly, and inhibition of K_V by fluoxetine during the 3 min period devoid of depolarizing pulses to +10 mV. This particular cell produced a 51% inhibition. Some recovery was possible upon wash-out.