Figure 4.
Concentration-response curve for the effect of isoprenaline on force of contraction in electrically driven left atria from wildtype and A1-adenosine receptor overexpressing mice. Isoprenaline (10 nM) was cumulatively applied to the organ bath. The transgenic lines of mice exhibited increasing levels of receptor overexpression in the order of lines 8, 1 and 5. Numbers in brackets indicate number of individual right atria. Asterisks indicate a significant difference between wild-type and transgenic lines and crosses indicate a significant difference from Ctr.