Figure 5.

Effect of indomethacin, DFU and dexamethasone on gastric mucosal PGs. Mucosal fragments were incubated in Tyrode solution at 37°C for 10 min and release of PGs into the medium was measured by RIA. Rats were sham operated (Sham op) or subjected to ischaemia for 30 min followed by reperfusion for 60 min (Co). Additional groups of rats were pretreated with indomethacin (Indo, 10 mg kg⁻¹), DFU (2 mg kg⁻¹) or dexamethasone (Dexa, 1 mg kg⁻¹) before I-R. Bars represent the mean±s.e.mean of 6–8 experi-ments; vehicle-treated rats were combined. ^***P<0.001 vs I-R alone.